Health economic burden that different wound types impose on the UK’s National Health Service
Resource use associated with managing the unhealed wounds was substantially greater than that of managing the healed wounds. Hence, the patient care cost of an unhealed wound is considerably higher than that of a healed wound.
Prospective and randomized evaluation of the protease-modulating effect of oxidised regenerated cellulose/collagen matrix treatment in Pressure sore ulcers.
PROMOGRAN™ improves healing rates in pressure ulcers and rebalances the wound environment.
Use of a protease modulating matrix in the treatment of pressure sores.
PROMOGRAN™ usage as part of an overall strategy in the treatment of pressure sores provides shortened healing times while also improving the overall management of these wounds.
A randomized controlled study evaluating the clinical benefits of a cellulose acetate mesh coated with a soft silicone in the management of acute wounds.
ADAPTIC TOUCH™ minimises adherence in acute wounds and is equivalent to the current market leader.
Meta-Analysis of Comparative Trials Evaluating a Single-Use Closed-Incision Negative-Pressure Therapy System
For all meta-analyses performed using the fixed-effects approach, ciNPT usage (PREVENA) demonstrated a statistically significant reduction in incidence of SSI relative to traditional dressings.
Closed Incision Negative Pressure Therapy is Associated with Decreased Surgical Site Infections: A Meta-analysis.
This meta-analysis suggests that closed incision negative pressure therapy (ciNPT) is effective in lowering the incidence of surgical site infections (SSIs) as compared to standard dressings.
A systematic review and meta-analysis including GRADE qualification of the risk of surgical site infections after prophylactic negative pressure wound therapy compared with conventional dressings in clean and contaminated surgery.
This meta-analysis indicates that prophylactic Negative Pressure Wound Therapy (pNPWT) significantly reduced the risk of SSIs.
Reduction of groin wound complications in vascular surgery patients using closed incision negative pressure therapy (ciNPT): a prospective, randomised, single-institution study
PREVENA™ Therapy significantly reduced the incidence of incision complications and revision procedures after vascular surgery.
Improving wound healing and preventing surgical site complications of closed surgical incisions: a possible role of Incisional Negative Pressure Wound Therapy. A systematic review of the literature
The literature showed a decrease in the incidence of infection, seroma/haematoma formation and on the re-operation rates when using iNPWT.
Negative Pressure Wound Therapy to Treat Hematomas and Surgical Incisions Following High-Energy Trauma
This RCT demonstrated decreased drainage and improved wound healing after the application of incisional NPWT following both hematomas and severe fractures.
Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty.
Pachowsky M, et al. Negative pressure wound therapy to prevent seromas and treat surgical incisions after total hip arthroplasty. International Orthopaedics. 2012 Apr;36(4):719-22.
Positive outcomes with negative pressure therapy over primarily closed large abdominal wall reconstruction reduces surgical site infection rates.
Compared to standard dressings, Closed Incision Negative Pressure Therapy decreased overall rate of SSI and hernia recurrence in patients undergoing abdominal wall reconstruction with STRATTICE™ Reconstructive Tissue Matrix
Effect of Single-Use Negative Pressure Wound Therapy on Postcesarean Infections and Wound Complications for High-Risk Patients.
Swift SH, Zimmerman MB, Hardy-Fairbanks AJ. Effect of Single-Use Negative Pressure Wound Therapy on Postcesarean Infections and Wound Complications for High-Risk Patients. Journal of Reproductive Medicine. 2015 June. 60(2):211-218.
Experience with a new negative pressure incision management system in prevention of groin wound infection in vascular surgery patients
PREVENA™ Therapy significantly decreased the incidence of groin wound infection in patients after vascular surgery and therefore was much more cost effective than intervention.
Systematic Review and Meta-analysis of the Open Abdomen and Temporary Abdominal Closure Techniques in Non-trauma Patients
In this review of the literature on OA and TAC in peritonitis patients, the best results in achieving delayed fascial closure and risk of enteroatmospheric fistula were shown for NPWT with continuous fascial retraction.
Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker's Vacuum Packing Technique.
Cheatham ML, et al. Prospective Study Examining Clinical Outcomes Associated with a Negative Pressure Wound Therapy System and Barker's Vacuum Packing Technique. World Journal of Surgery 2013 September 1;37(9):2018-30
Are Commercial Negative Pressure Systems Worth the Cost in Open Abdomen Management?
Frazee RC, et al. Are Commercial Negative Pressure Systems Worth the Cost in Open Abdomen Management? Journal of the American College of Surgeons 2013 April 1;216(4):730-3.
A prospective, multicentre study on the use of epidermal grafts to optimise outpatient wound management.
CELLUTOME™ System offers a novel method in autologous skin harvesting, resulting in minimal or no pain and scar-free donor site in the outpatient setting.
Epidermal Grafting Using a Novel Suction Blister–Harvesting System for the Treatment of Pyoderma Gangrenosum
Richmond NA, Lamel SA, Braun LR, Vivas AC, Serena T, Kirsner RS. Epidermal Grafting Using a Novel Suction Blister–Harvesting System for the Treatment of Pyoderma Gangrenosum. JAMA Dermatology epub 8/7/2014.
USE OF EPIDERMAL SKIN GRAFTS IN CHRONIC WOUNDS: A CASE SERIES
Use of epidermal skin grafts in chronic wounds: a case series, Peter AM Everts, Marco Warbout, Diana de Veth, Merel Cirkel, Nicole E Spruijt, Jaap Buth, International Wound Journal, Volume 14, Issue 6, December 2017
The CelluTome epidermal graft-harvesting system: a patient-reported outcome measure and cost evaluation study.
For the right patient, epidermal skin grafts provide comparable wound management as a split thickness skin graft (STSG) with reduced donor site morbidity.
Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation.
Kim PJ, Attinger CE, Oliver N, Garwood C, Evans KK, Steinberg JS, Lavery LA. Comparison of Outcomes for Normal Saline and an Antiseptic Solution for Negative-Pressure Wound Therapy with Instillation. Plast Reconstr Surg. 2015 Nov;136(5):657e-64e.
First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study.
Lehner B, et al. First experiences with negative pressure wound therapy and instillation in the treatment of infected orthopaedic implants: a clinical observational study. Int Orthop 2011 September 1;35(9):1415-20
Negative pressure wound therapy with instillation: a pilot study describing a new method for treating infected wounds
NPWT with 0.5% silver nitrate instillation showed a significant decrease in the mean time to bioburden reduction, wound closure and hospital discharge compared with traditional wet-to-moist wound care. NPWT with instillation may reduce cost and decrease inpatient care requirements for these complex, infected wounds.
The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study.
Kim PJ, Attinger CE, Steinberg JS et al. The impact of negative-pressure wound therapy with instillation compared with standard negative-pressure wound therapy: a retrospective, historical, cohort, controlled study. Plastic and Reconstructive Surgery. 2014 March 1;133(3):709-16.
Negative pressure wound treatment with polyvinyl alcohol foam and polyhexanide antiseptic solution instillation in posttraumatic osteomyelitis
In post-traumatic osteomyelitis negative pressure instillation therapy significantly reduces the need for repeated surgical interventions, aids in the reduction of the rate of recurrence of infections and the duration of hospital stay in comparison with the standard approach.
Implant salvage in breast reconstruction with severe peri-prosthetic infection
VERAFLO™ Therapy with saline was used as part of an implant salvage protocol for patients with severe peri-prosthetic infection following breast reconstruction.
Negative pressure wound therapy with saline instillation: 131 patient case series.
NPWTi with saline, after proper debridement, was sufficient to shift the wound healing trajectory from risk of infection and delayed healing to granulation formation.
Sterile-water negative pressure instillation therapy for complex wounds and NPWT failures.
Fluieraru S, et al. Sterile-water negative pressure instillation therapy for complex wounds and NPWT failures. Journal of Wound Care. 2013 Jun 12;22(6):293-9.
A Multicenter Randomized Controlled Trial Comparing Treatment of Venous Leg Ulcers Using Mechanically Versus Electrically Powered Negative Pressure Wound Therapy
This study compares SNAP™ Therapy System with V.A.C.® Therapy and concludes that the mechanically powered negative pressure wound care system shows greater improvement of complete wound closure.
Comparative effectiveness of mechanically and electrically powered negative pressure wound therapy devices: A multicenter randomized controlled trial
This study compares the SNAP™ Therapy System with V.A.C.® Therapy in the treatment of chronic lower extremity wounds and shows that both therapy systems reveal comparable clinical outcomes
Evaluation of Chronic Wound Treatment with the SNaP Wound Care System versus Modern Dresing Protocols
SNAP™ Therapy System showed similar clinical outcomes as powered negative-pressure wound therapy devices for the treatment of highly challenging lower extremity wounds.
A randomised study of NPWT closure versus alginate dressings in peri-vascular groin infections: quality of life, pain and cost.
In patients with deep peri-vascular groin infection, NPWT therapy was regarded as the dominant strategy, due to improved clinical outcome, with equal measures of cost and quality of life.
Use of Vacuum Assisted Closure Therapy in the Treatment of Diabetic Foot Wounds
Treating diabetic wounds with V.A.C.® Therapy can result in faster wound bed preparation, a faster closure, and in a better graft take rate when compared to standard wound care.
Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial.
Blume PA, et al. Comparison of negative pressure wound therapy using vacuum-assisted closure with advanced moist wound therapy in the treatment of diabetic foot ulcers: a multicenter randomized controlled trial. Diabetes Care 2008 April 1;31(4):631-6.
State-of-the-art treatment of chronic leg ulcers: A randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings.
Vuerstaek JD, et al. State-of-the-art treatment of chronic leg ulcers: A randomized controlled trial comparing vacuum-assisted closure (V.A.C.) with modern wound dressings. Journal of Vascular Surgery 2006 November 1;44(5):1029-38
Comparison of health care costs and hospital readmission rates associated with negative pressure wound therapies.
Law A, Cyhaniuk A, Krebs B. Comparison of health care costs and hospital readmission rates associated with negative pressure wound therapies. Wounds. 2015 Mar;27(3):63-72.
Negative-pressure therapy versus standard wound care: a meta-analysis of randomized trials.
Suissa D, Danino A, Nikolis A. Negative-pressure therapy versus standard wound care: a meta-analysis of randomized trials. Plast Reconstr Surg. 2011 Nov;128(5):498e-503e.
Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation.
Morykwas MJ, Argenta LC, Shelton-Brown EI, McGuirt W. Vacuum-assisted closure: a new method for wound control and treatment: animal studies and basic foundation. Ann Plast Surg. 1997 Jun;38(6):553-62.
Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial.
Mouës CM, Vos MC, van den Bemd GJ, Stijnen T, Hovius SE. Bacterial load in relation to vacuum-assisted closure wound therapy: a prospective randomized trial. Wound Repair Regen. 2004 Jan-Feb;12(1):11-7.
Vacuum-assisted wound closure after resection of musculoskeletal tumors.
Bickels J, Kollender Y, Wittig JC, Cohen N, Meller I, Malawer MM. Vacuum-assisted wound closure after resection of musculoskeletal tumors. Clin Orthop Relat Res. 2005 Dec;441:346-50.
Innovation in wound management with disposable, portable, cost-effective and non-powered NPWT device: Experience in general surgery
In this case series of three patients, the use of NANOVA™ Therapy System positively affected the clinical outcome and resulted in early discharge from hospital, quicker recovery and early return to daily activities.
AUTOLOGOUS FAT GRAFTING TO THE BREAST USING REVOLVE™ TO REDUCE CLINICAL COSTS
Autologous fat grafting to the breast using REVOLVE to reduce clinical costs. Jarrell JA IV, Brzezienski MA. Ann Plast Surg. 2016 Sep;77(3):286-9. doi: 10.1097/SAP.0000000000000590
EFFICACY OF ACELLULAR DERMAL MATRICES IN REVIONARY AESTHETIC BREAST SURGERY: A 6- YEAR EXPERIENCE
Efficacy of Acellular Dermal Matrices in Revisionary Aesthetic Breast Surgery: a 6-year Experience, Maxwell et al., Aesthet Surg J. 2013 Mar;33(3):389-99. doi: 10.1177/1090820X13478967. Epub 2013 Feb 25
PROSPECTIVE STUDY OF SINGLE-STAGE REPAIR OF CONTAMINATED HERNIAS USING A BIOLOGIC PORCINE TISSUE MATRIX
Prospective study of single-stage repair of contaminated hernias using a biologic porcine tissue matrix: The RICH Study, Itani KM, Rosen M, Vargo D, Awad SS, Denoto G 3rd, Butler CE; RICH Study Group, Surgery; 152(3):498-505
IMPROVED OUTCOMES IN THE MANAGEMENT OF HIGH-RISK INCISIONAL HERNIAS UTILIZING BIOLOGICAL MESH AND SOFT-TISSUE RECONSTRUCTION IN A SINGLE CENTER EXPERIENCE
Improved Outcomes in the Management of High-Risk Incisional Hernias Utilizing Biological Mesh and Soft-Tissue Reconstruction a single center Experience, Dinakar et al., Int Surg. 2014 May-Jun;99(3):235-40. doi: 10.9738/INTSURG-D-13-00170.1
VENTRAL HERNIA: RETROSPECTIVE COST ANALYSIS OF PRIMARY REPAIR, REPAIR WITH SYNTHETIC MESH, AND REPAIR WITH ACELLULAR XENOGRAFT IMPLANT
Ventral Hernia: Retrospective Cost Analysis of Primary Repair, Repair with Synthetic Mesh, and Repair with Acellular Xenograft Implant, DeNoto et al., Open Access Surgery, May 2013
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